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Adults with disease progression on previous therapies were eligible. Further research is needed to clarify the significance of these findings. The her3 protein, that belongs to the erbb/her receptor tyrosine kinase (rtk) family, is expressed in several types of tumors
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That fact, together with the role of her3 in promoting cell proliferation, implicate that targeting her3 may have therapeutic relevance. Monoclonal antibodies and bispecific antibodies targeting her3 have led to unsatisfactory results. In this review, we discuss the her3 role in the pathogenesis of breast cancer and its relevance across all subtypes
Her3 is a member of the her/erbb family of receptor tyrosine kinases, together with egfr (her1), her2 and her4
Despite having only weak intrinsic kinase activity, her3 can contribute to. Patritumab deruxtecan shows meaningful clinical activity in heavily pretreated patients with metastatic breast cancer and active brain metastases, a phase 2 trial reports. Her3 is a tyrosine kinase receptor belonging to the her family, ubiquitously expressed across different solid tumors Her3 has a role in tumorigenesis, disease progression, metastatic dissemination and anticancer drugs’ resistance
