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Nucleoside analogues are structural analogues of a nucleoside, which normally contain a nucleobase and a sugar Currently, nucleoside analogs are mainly obtained through nucleic acid degradation, chemical synthesis, and biotransformation. Nucleotide analogues are analogues of a nucleotide, which normally has one to three phosphates linked to a nucleoside.
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This review explores the mechanisms of action, pharmacokinetics, and safety profiles of these nucleoside analogs. Their structural alterations enable them to. Nucleoside analogues are synthetic or natural compounds that mimic the structure of nucleosides, the building blocks of nucleic acids (dna and rna)
These analogues have been extensively studied and developed for various applications in medicine, research, and diagnostics.
Two key aspects are covered, the first surrounding methodology concepts, effectively using enzymes to access diverse nucleoside analogue space and also for producing key building blocks The second focuses on the use of biocatalytic cascades for de novo syntheses of nucleoside analogue drugs. A team of researchers has found a quicker and more efficient way to create nucleoside analogs, a type of small molecule that can be used in treatments for everything from cancer to viral. Nucleoside analogues are modified forms of natural nucleosides that have become indispensable in both therapeutic and diagnostic applications
