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As of august 2022, 125 patients (60% male) had a mean migalastat exposure of 3.9 years. Food and drug administration (fda), offering an alternative approach for certain patients. Until a few years ago, treatment options for fabry disease were limited to enzyme replacement therapy with agalsidase alfa or beta administered by intravenous infusion every 2 weeks
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Migalastat (galafold ®) is an oral pharmacological chaperone that increases the enzyme activity of “amenable” mutations. But in 2018, a new oral therapy called galafold® (migalastat) was approved by the u.s Galafold is the world's first oral treatment for fabry disease, developed by amicus therapeutics and distributed in korea by handok
(courtesy of handok) because fabry disease is a progressive lysosomal storage disorder with symptoms often beginning in childhood, early diagnosis and treatment are critical for pediatric patients.
For many years, enzyme replacement therapy (ert) was the only available treatment for fabry disease
